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Some researchers report that their "problem areas" start responding in ways that diet and cardio alone hadn't moved
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However, the requirement for HSL phosphorylation has recently been challenged as studies by the Granneman group elegantly show that direct activation of PNPLA2 in the absence of PKA stimulation is sensitive to HSL inhibition, suggesting that PNPLA2-mediated generation of DAG is sufficient to promote HSL activity (49)
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