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Division of Dermatology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa ABSTRACT BACKGROUND: Glutathione (GSH) is the most abundant naturally occurring non-protein thiol that protects mammalian cells from oxidative stress

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Also, obesity disrupts the hypothalamic-pituitary-gonadal axis, causing hypogonadism and testosterone deficiency, while adipose-mediated aromatization of testosterone to estrogen exacerbates hormonal dysregulation