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In CRC cells, the mutant isocitrate dehydrogenase 1 inhibitor Ag120 inhibited ASCT2-mediated Gln uptake, leading to decreased cell proliferation and increased oxidative stress both in vitro and in vivo [63]

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When used, T 4 treatment of Tg-KO mice was performed by supplementation of drinking water with T 4 (1 μg/mL, T2501, MilliporeSigma)

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