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NICE guidance recommends early referral (within 3 working days) for suspected persistent synovitis to enable prompt initiation of disease-modifying therapy where appropriate
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Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design
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