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Below are possible Vitamin B12 deficiency symptoms: Weakness, tiredness, or lightheadedness Heart palpitations and shortness of breath Pale skin A smooth tongue Constipation, diarrhea, loss of appetite, or gas Nerve problems like numbness or tingling, muscle weakness, and problems walking Vision loss Mental problems like depression, memory loss, or behavioral changes You can also get vitamin B12 deficiency if you follow a vegan diet or you are a vegetarian who doesn't eat enough eggs or dairy products to meet your vitamin B12 needs
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Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis