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Under pristine conditions, you would naturally produce enough antioxidants to completely neutralize free radicals and prevent them from causing oxidative damage
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Moreover, the same NO/cGMP signaling was effective in survival cell response to GSH depletion in skeletal muscle cells ( On the basis of these knowledge, it is not surprising that alterations in GSH homeostasis have been implicated in the etiology and/or progression of many human diseases (Liu et al., 2004)
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