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Metabolic Decompensation after VitB12 Deficiency The deficiency of VitB12, or more specifically, the alterations in MTR or MUT (for which VitB12 serves as a cofactor), not only avoids the biosynthesis of reaction intermediates but also determines the accumulation of substrates that are toxic at higher concentrations (Figure 2)

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Since these compounds are water-soluble, the body may safely process them without risk of accumulation [11]