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The suggestion that reduced nuclear environment could protect oxidant sensitive proteins from oxidation [50] could be confirmed by our results: there was less glutathionilated and more oxidised proteins when the nuclear GSH was depleted by DEM (Fig
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C ssav = AUC 0–t /τ, τ is the interval of administration;C ssmin =(C -48h + C -24h + C 0h )/3
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