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In the following sections, we will summarize the current findings on the molecular and cellular mechanisms involved, discuss their relevance in overcoming therapy resistance, and outline the potential benefits and limitations of this multimodal approach

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Electrons can also prematurely “spin-off” from prosthetic groups in Krebs cycle enzymes and respiratory complexes and univalently reduce di-oxygen to generate reactive oxygen species (ROS) superoxide (O 2 • − ) and hydrogen peroxide (H 2 O 2 ), important signaling molecules that can be toxic at high concentrations