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Demonstrating safety and effectiveness necessitates rigorous trials with reproductive endpoints, long-term offspring follow-up, and pharmacovigilance systems

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doi: 10.3389/fphar.2018.01162 Received 30 May 2018 Accepted 24 September 2018 Published 16 October 2018 Volume 9 - 2018 Edited by Andres Trostchansky, Universidad de la República, Uruguay Reviewed by Suowen Xu, University of Rochester, United States