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CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-β, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)
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Similarly, the co-cultivation of a folate producer, Lactobacillus plantarum , with a vitamin B 12 producer, Propionibacterium freudenreichii , in a whey permeate medium led to a natural dietary supplement with an optimal ratio of folate and vitamin B 12 146,847–852