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Its TME often displays immunosuppression, marked by a preponderance of regulatory T (Treg) cells, myeloid-derived suppressor cells, and M2 macrophages, which facilitate immune evasion ( Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, and multiple sclerosis ( In this review, we discuss how peptide-based tumor immunotherapy transforms PCa from a “cold” to a “hot” state by modulating the TME of PCa and inducing ICD in PCa cells, thereby enhancing the response of PCa to immunotherapy