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# NBP2-29447, Novus Biologicals, Littleton, CO, United States), according to the manufacturer’s instructions, and the resulting fractions were subjected to Western blot analysis under the same conditions

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Focal hypoechoic lesions with a hyperechoic center or core (referred to as target or bull's-eye lesions) are usually associated with metastases, although some benign processes, such as nodular hyperplasia, can generate similar patterns