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This vicious cycle perpetuates epigenetic deregulation via histone and DNA hypermethylation (51), impairs collagen maturation and EGF signaling (136), and drives the progression of diverse cancers, including glioma, glioblastoma, acute myeloid leukemia (AML), intrahepatic cholangiocarcinoma, melanoma, angioimmunoblastic T-cell lymphoma (AITL), chondrosarcoma, sporadically in melanoma, medulloblastoma, astrocytomas, hepatocellular, oligodendrogliomas, oligoastrocytomas, squamous cell carcinoma, colon carcinoma, nasopharyngeal carcinoma, sarcoma, stromal tumors, cervical cancer, gastric cancer, renal carcinoma, lung cancer, ovarian cancer, thyroid cancer, breast cancer, and pancreatic cancer (24, 39, 40, 50, 57, 61, 62) ( Figure 7 )
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