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🔹 Clinical Importance • ACE inhibitors (e.g., Captopril, Enalapril) → block conversion of Angiotensin I to II → lower BP

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The emphasis was on NO, carbon monoxide and hydrogen sulfide[24-26], sulfhydryls (SH)[20,27,28] in parallel with prostaglandins, as well as histamine[23], prostaglandins[17], EP1 and IP receptors[29,30], the healing action of antacid[31], sucralfate[31,32], heat shock protein 70 (HSP70)[33], and the renin-angiotensin system and active angiotensin metabolites[34]