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Published preclinical studies have investigated 5-Amino-1MQ as a selective inhibitor of Nicotinamide N-methyltransferase (NNMT) in laboratory models (Neelakantan et al., 2018)

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The presence of the enzyme in adrenal and reproductive tissues suggests a potential role in hormone-regulated steroidogenesis and possibly in sperm development, by regulating the availability of free cholesterol (6)

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