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It is commonly examined in tissue integrity studies, gastrointestinal simulations, vascular signaling experiments, inflammatory pathway research, and exploratory neurological models
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Interestingly, a recent study showed that oral supplementation of NR altered the intestinal microbial composition in rats and mice but not humans 63 , highlighting the need for further studies on this matter to assess the impact of NAD + metabolism modulation by the microbiome on health outcomes
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