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Recommended Adult and Pediatric Dosage (2.5): • Acetylcysteine is for intravenous administration only • Total dosage of acetylcysteine is 300 mg/kg given intravenously as 3 separate doses and total recommended infusion time for 3 doses is 21 hours • See Full Prescribing Information for weight-based dosage and weight-based dilution (2.5) • See Full Prescribing Information for recommendations for continuing acetylcysteine treatment after 21 hours (2.2) Repeated Supratherapeutic Acetaminophen Ingestion (2.6): • Obtain acetaminophen concentration and other laboratory tests to guide treatment

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Pediatrics 135 , 213–223 (2015)

playing a crucial role in protecting against oxidative stress and free radicals