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For men, while baseline estrogen levels are significantly lower, conditions that disrupt androgen-estrogen balance—such as Klinefelter syndrome, obesity-induced aromatase activation, or chronic liver disease—markedly increase BC susceptibility (Sah et al., 2026)
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PFAS has been shown to cluster into a higher-order assembly with other enzymes in purine biosynthesis, named purinosome, under purine-depleted conditions (Pedley et al., 2022)