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BRD7 IC 50 = 41 nM for the dimethyl pyridone analogue) 27 , but no degradation of BRD7 was observed in this experiment, suggesting that selectivity of the compound AMPTX-1 may come from more effective and functional ternary complex formation and target ubiquitination, and not from selective target engagement
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This has been confirmed with in vitro studies on male SCN, showing that simulated light exposure using NMDA on SCN explants induces distinct electrophysiological responses compared to females 94 , suggesting differential phase-shifting capabilities in both sexes
