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Elevated NAD+ activates sirtuins (SIRT1, SIRT3)

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A seminal cost analysis published in Canadian Family Physician (2001) projected that switching patients from intramuscular B12 injections to oral supplements could save between $2.9 million and $17.6 million depending on the population studied – with one Ontario analysis estimating $14.5 million in savings for 110,000 elderly patients