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Dysregulation of FXN protein function in ISC assembly can produce several alterations in cells, including those produced by deficits in Fe-S cluster-containing mitochondrial enzymes, such as aconitase and succinate dehydrogenase

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222 NE and MMP9 from NETs remodel laminin, an important component of the extracellular matrix (ECM), activating integrin α3β1 signaling and promoting proliferation of dormant cancer cells