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( A ) Volcano plots highlight 3034 and 2484 differential metabolites (unique molecular formulas were determined by high-resolution, accurate intact mass, isotopic patterns, and MS/MS analyses) for negative and positive ion modes (left and right), respectively
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Common experiences after the first injection include: Mild soreness or redness at the injection site (usually resolves within 1–2 days) Slight improvement in energy levels or mood No immediate noticeable change (particularly common if deficiency is severe) Rarely, mild side effects such as headache or dizziness Some patients report their urine becoming brighter or more intensely coloured following injection, which occurs because excess B12 is excreted renally